In the late ‘80s Dr. Hargreaves invented a method to assess thermal pain sensation in unrestrained rodents by stimulating the single hind paw and thus allowing for unilateral/contralateral experiments. Ugo Basile made a science-grade instrument to perform this stimulation and automatically measure response and it became a gold-standard with more than 2,000 publications in 2022.

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Records and analyses thermal preference phenotyping in mice, according to Zimmermann's method. For neuropathic pain studies, temperature sensitivity and insensitivity assessment, always with the animal freely moving and with no user’s intervention.

Novel circular design. Addresses limitations associated with classic devices. Cost effective. Reproducible data.

Measures endurance, distance and speed. For studying behavioral, physiological, biochemical, and molecular responses to both acute exercise stress and chronic exercise training.

Original product by Ugo Basile is adaptable for use by rats or mice. Easy set up and control using touch screen. Automatic measurement of endurance, distance and speed. Shock grid for aversive stimulus (if...

Measures the weight distribution difference between an injured and unaffected hind paw of a mouse or rat. For the assessment of spontaneous pain in osteoarthritis, bone cancer, nerve injury and post-operative pain studies. Automatic operation reduces operator bias, optimizes repeatability and saves time. Easy to set up. Data visualization to monitor trends. Fast and easy cleaning...

Measures hypersensitivity to thermal (hot and cold) and/or mechanical stimulation of the orofacial area in rats (mouse adaptor available). For research into a wide range of pain conditions involving the trigeminal nerve.

High throughput with data recorded from up to 16 cages with ORO-Software. Real time data display. Non-invasive, respectful test. Comprehensive metrics and easy data...

Identifies temperature sensitivity and nociceptive pain thresholds. For pathophysiological exploration of animal pain models and pharmacological assessment of analgesic drugs. Often called the Two-Temperature Choice Test.

Easy touch screen controls for setting up and monitoring tests. Fast data portability. Fixed or ramp temperatures for dynamic experiments.

Measures small changes in volume & oedema (fluid retention) to gauge the inflammatory response such as for anti-inflammatory screening tests.

Hands-free operation. Precision measurements. Detects and displays 0.01 ml changes in rodent paw volume. Easy data transfer and software included.

Accurately measures the nociceptive threshold to infrared heat stimulus on the rat or mouse tail. Used for rapid screening of analgesic drugs by measuring reaction time to heat, even in anesthetized animals, crucial for repeated tests, thanks to the reflexive nature of the tail flick response.

Adjustable I.R. intensity, bright touch-screen display with intuitive controls. Comfortable...

Measures the force on a rat or mouse paw according to the Randall-Selitto paw-pressure test, it enables rapid and precise screening of analgesic drugs for anti-nociceptive studies, in healthy or inflamed limbs. The device applies a steady increasing force, starting and stopping using the foot pedal. No calibration required. Digital model with force sensors and electronic unit is also...

Provides simple, reliable and precise calibration for Ugo Basile Plantar Test & Tail Flick and other infrared (I.R.) analgesia meters.

The hot cold plate test has been the gold standard test for thermal pain tests in rodents for decades. Through the years the devices have been improving and the techniques have become more sophisticated, adding to constant temperature methods also other ones.

The Ugo Basile Hot/Cold plate test includes all the latest technologies necessary to run constant temperature, linear ramping...