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Animal
Rat
Orofacial Stimulation Test - Fehrenbacher, Henry, Hargreaves method
Product Code:31300/31320/31340
Category: Pain and Inflammation
Measures hypersensitivity to thermal (hot and cold) and/or mechanical stimulation of the orofacial area in rats (mouse adaptor available). For research into a wide range of pain conditions involving the trigeminal nerve.
High throughput with data recorded from up to 16 cages with ORO-Software. Real time data display. Non-invasive, respectful test. Comprehensive metrics and easy data transfer for more analysis.
No vibrissae area shaving needed, avoiding animal discomfort and experimental perturbation.
Background
- One of the few methods available for orofacial preclinical research.
- Orofacial pain is one of the most common neurological complaints.
- The Orofacial Stimulation Test by Ugo Basile uniquely measures hypersensitivity to thermal or mechanical stimulation of the trigeminal nerve in rats and mice
- Fehrenbacher, Henry, Hargreaves method, hence the credibility of highly cited scientists
- Integrates higher-order brain (cognitive) functions into measurements of orofacial nociception
High throughput, simultaneous measurement
- Rats voluntarily access a food reward or avoid the aversive stimulus.
- Simultaneous measurement of nociceptive responses to thermal and/or mechanical stimulation.
- Non-invasive - does not require shaving. Stimulator contacted with animal vibrissae pad.
- Metrics include duration of feeding and the number of feeding attempts measured by interruption of an infrared barrier as the animal attempts to obtain the reward.
- Water temperature can be adjusted from ambient to 70ºC.
- High throughput - data from up to 16 cages can be recorded simultaneously and displayed in real time using ORO-Software.
- Data can be displayed in numeric and graphic format.
- Data are automatically analysed across time according to an adjustable time window, independently viewable for each of the 16 cages.
- Test results can be saved in spreadsheet format for easy transfer to other programs for more analysis.
- Adaptors for Mice are available.
- Device fits in standard home cages for easy training and testing
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Mechanical and Thermal nociception assays within the same experiment |
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Integrates higher-order brain functions into measurements of orofacial nociception |
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Intact vibrissal pad, as the test does not require any vibrissal shaving |
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High throughput: up to 16 animals can be tested simultaneously |
| General | |||
|---|---|---|---|
| Water Temperature | Can be adjusted from ambient to 70°C | ||
| Mechanical Stimulation | 3 mechanical Stimulators with different wire number, and 1 blank | ||
| Oro Software | Collects and records beam-break number and duration from up to 16 cages simultaneously | ||
| Operating Temperature |
10°C to 40°C; 5% to 95% RH (non-condensing) |
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| Sound Level | Negligible | ||
| Pollution Degree | ≤ 2 | ||
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Physical | |||
| Product Code | Net Weight | Shipping Weight | |
| 31300 Net Weight |
13Kg |
15Kg | |
| 31320 Net Weight | 23Kg | 28Kg | |
| 31340 Net Weight | 38Kg | 43Kg | |
|
Warranty | |||
| Warranty | Orofacial System is covered by a 12-month warranty + 12 after product registration | ||
| UB-Care | Additional UB-Care can be added for other 12 or 24 months | ||
Orofacial pain problems are common and involve structures and mechanisms unique to the trigeminal nerve. Few methods are currently available for orofacial preclinical research, and none incorporates parallel measurement of mechanical or thermal stimulation within the same experiment.
Moreover, while most of the current assays measure unlearned behaviors, such as flinching or withdrawal reflexes, the new Orofacial Stimulation Test, developed by Fehrenbacher, Henry and Hargreaves, integrates higherorder brain functions into measurements of orofacial nociception.
This innovative approach permits highly integrated nociceptive responses to thermal or mechanical stimulation.
Animals are trained & tested in standard home cages. Tests are performed in the presence of thermal or mechanical stimuli contacting the vibrissal pad. Following treatment to induce hypersensitivity, (e.g., trigeminal ligation or injection) trials are repeated to determine the effect of treatment on feeding behavior/reward. Assay sensitivity (inflammation-induced decreases in feeding behavior and reversal of hypersensitivity by local and systemic administration of analgesics) has been proven (Hargreaves et alia, ms in prep.); the feeding behavior is strongly correlated to mechanical or thermal orofacial nociception, as the animal must contact the stimulator in order to access the food reward.
Orofacial pain problems are common and involve structures and mechanisms unique to the trigeminal nerve.
Few methods are currently available for orofacial preclinical research and none incorporates parallel measurement of mechanical or thermal stimulation within the same experiment.
Moreover, while most of the current assays measure unlearned behaviors, such as flinching or withdrawal reflexes, the Orofacial Stimulation Test, developed by Dr. Fehrenbacher, Henry and Hargreaves, integrates higher order brain functions into measurements of orofacial nociception.
| 31300 Orofacial Orofacial Stimulation Test, Complete System for one anima | |
|---|---|
| 31300-001 | Electronic unit (four channels) |
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31300-002 |
Additional cage assembly (includes thermal and mechanical stimulators and feeding detector) |
| 31300-003 | Circulating water bath |
| 31300-010 | ORO-Software, for data acquisition and analysis from up to 16 cages |
| E-AU 101 | USB pen-drive, including Instruction Manual |
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31320 Orofacial Stimulation Test, Complete System for two animals | |
| 31300-001 | Electronic unit (four channels) |
|
31300-002 |
Additional cage assembly (includes thermal and mechanical stimulators and feeding detector) |
| 31300-003 | Circulating water bath |
| 31300-010 | ORO-Software, for data acquisition and analysis from up to 16 cages |
| 31300-320 | Water Distributor (for 2 and 4-cage systems only) |
| E-AU 101 | USB pen-drive, including Instruction Manual |
|
31340 Orofacial Stimulation Test, Complete System for four animals | |
| 31300-001 | Electronic unit (four channels) |
|
31300-002 |
Additional cage assembly (includes thermal and mechanical stimulators and feeding detector) |
| 31300-003 | Circulating water bath |
| 31300-010 | ORO-Software, for data acquisition and analysis from up to 16 cages |
| 31300-320 | Water Distributor (for 2 and 4-cage systems only) |
| E-AU 101 | USB pen-drive, including Instruction Manual |
|
Optional | |
| 31300-323 | Kit of Mouse adaptors for thermal and mechanical stimulation (for 1 cage) |
J.C. Fehrenbacher et alia: “Characterization of a novel orofacial behavioral assay to assess hyperalgesia to thermal and mechanical stimulation”. (submitted).