Measures the weight distribution difference between an injured and unaffected hind paw of a mouse or rat. For the assessment of spontaneous pain in osteoarthritis, bone cancer, nerve injury and post-operative pain studies. Automatic operation reduces operator bias, optimizes repeatability and saves time. Easy to set up. Data visualization to monitor trends. Fast and easy cleaning procedures.
Also called “Incapacitance Tester” or “Static Weight Bearing”, it is the classic method to assess unilateral pain (especially joint pain, but also neuropathic pain, etc.), as when the animal stands on the force sensors (one per hind paw), it makes a natural adjustment to the degree of pain, by adapting weight distribution on both rear paws.
Shifts in pain distribution between limbs serve as indicators of pain severity, offering a quantitative and simple method to quantify the extent of weight distribution imbalances caused by pain. Weight bearing devices can also be used in longitudinal studies to understand pain progression and effectiveness of treatments, to screen potential drug candidates as well as in translational studies.
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Features |
Benefits |
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Measure hind paw weight distribution |
The most widely used method for weight bearing (>1,500 citations) is now updated and equipped with the latest technologies by Ugo Basile. |
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Autostart is a unique feature |
Automate the measurement process by identifying immobility windows. |
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Touch screen and USB data storage |
Let scientists setting, controlling and managing instrument data quickly and seamlessly. Through a few, intuitive buttons, one can reach all the functionalities. The included USB key stores all data for optimal portability (average paw weight, Standard Deviation, Left/Right ratio, etc.). The Left/Right weight histograms and scatter charts display on line the experiment output for an immediate visual control, graphically effective and easy to follow during the test. |
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Reliable and easy to collect results:, software included |
High quality force sensors (0.1g resolution) are easily calibrated with the provided reference weight and show no screws or other parts potentially interfering with the animal, for maximum experiment repeatability. After each test the result can be stored or discarded and data can be transferred from the instrument to a PC for MS Excel. At the end of the experiment the foot pads can be cleaned in a few seconds, being magnetically attached to the base. |
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General | |
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| Command input and read-out |
4,3 inches touch-screen (Resistive) |
| Power Requirements |
Universal input 100-240 VAC, 50-60Hz, 15W max |
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Sound Level |
Negligible |
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Operating Environment |
10°C to 40°C; 5% to 95% RH (non-condensing) |
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Operation | |
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Animal weight (per paw) |
From 20g to 2200g |
| Precision | From 0.05% to 0.1% |
| Measurement time | From 1s to 360s |
| Measurement starting mode | Manual and Automatic |
| Calibration | Automatic |
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Start |
Start button, Pedal Switch, or Autostart |
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Stop |
Stop button, Pedal Switch, or Elapsed Timeout |
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Data Export |
.csv format, from USB key (provided) |
| TTL I/O | Start, Stop, Mode |
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Physical | |
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Dimensions: |
25 cm x 31 cm x 13 cm |
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Packaging dimension: |
68 cm x 34 cm x 28 cm |
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Weight: |
2.5 Kg |
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Warranty | |
| Warranty | Librae is covered by a 12-month warranty + 12 months after product registration |
| UB-Care | Additional UB-Care can be added for other 12 or 24 months |
Weight distribution is especially important in conditions where musculoskeletal and neurological systems are affected. The most typical is Osteoarthritis, a degenerative joint disease where joint cartilage breaks down. It is broadly used also in rheumatoid arthritis, where the autoimmune mechanism ends up with joint inflammation and relative pain.
The altered sensation typical of neuropathic pain, especially when unilateral nerve injury models are used, can lead to abnormal weight distribution, quantifying how neuropathic pain influences gait and balance. The same applies to diabetic neuropathies.
Also, stroke can lead to altered weight distribution as a result of the associated motor impairments and adaptations to their motor deficits, resulting in abnormal weight distribution. Recovery of weight distribution is tracked during injury rehabilitation studies.
In summary, weight distribution measurement is a valuable tool in pharmacology, phenotyping, validation of animal models, translational studies, relatively to a broad number of treatments and diseases.
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47882 Librae for Rats | |
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| 47880-001 | Librae Incapacitance tester, max load 2.2Kg. per paw, resolution 0.1 g, USB data export, self calibration and autostart modes, no restrainer, pedal switch, calibration weight, Included |
| 47880-002 | Librae Incapacitance tester restrainer for rat in clear perspex, width 64 mm |
| 47880-321 | Librae Incapacitance tester magnetic pads (pair left + right) |
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47883 Librae for Mice | |
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| 47880-001 | Librae Incapacitance tester, max load 2.2Kg. per paw, resolution 0.1 g, USB data export, self calibration and autostart modes, no restrainer, pedal switch, calibration weight, Included |
| 47880-003 | Librae Incapacitance tester restrainer for mice in clear perspex, width 40 mm |
| 47880-320 | Librae Incapacitance tester calibration weight 100 gr. |
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47885 Librae Combo for Mice and Rats | |
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| 47880-001 | Librae Incapacitance tester, max load 2.2Kg. per paw, resolution 0.1 g, USB data export, self calibration and autostart modes, no restrainer, pedal switch, calibration weight, Included |
| 47880-002 | Librae Incapacitance tester restrainer for rat in clear perspex, width 64 mm |
| 47880-003 | Librae Incapacitance tester restrainer for mice in clear perspex, width 40 mm |
| 47880-321 | Librae Incapacitance tester magnetic pads (pair left + right) |
| Options | |
| 47880-004 | Librae Incapacitance tester restrainer for fat rat in clear perspex |
V. Batchelor, J. Miotla-Zarebska T.L. Vincent, 2022, “Refining methods to measure spontaneous pain behaviour in surgically induced murine osteoarthritis”, Osteoarthritis and Cartilage
In addition to the one-year Regular Warranty and in addition to the one-year product registration extended warranty, Ugo Basile offers an Optional Extended Warranty that extends the warranty period for the product for additional one or two years called “UB Care12”/“UB Care24”. Customers may purchase the “UB Care” at the maximum of 3 months after buying. For more detailed information, please contact your local representatives.
